Nanosmiles

Nanosmiles is a Japanese arena shooter where the vague, drawn introduction appears to suggest the world is on the brink of destruction. A girl imprints a message in the DNA of a cell organism before everything around her disappears. In sixteen levels players control a small blue object in enclosed areas. It can be moved around and dash for a short distance with an additional key.

In each of the areas, the player needs to defeat all other organisms. With no means of defence, it needs to activate so-called options, brown equivalents of itself that are able to shoot. The player then targets the enemies, dodging bullets, while the options that follow it shoot opponents. It is the player who has to press a key to command them to shoot. As soon as an option is hit, it is deactivated and the player's organism needs to move over it for revival. When disabled options are left lingering too long, they disappear. As soon as the player's organism is hit, the game is over. Certain enemies also leave behind new options.

While playing, new music tracks are unlocked progressively and any track can be chosen before playing a level. There is a short tutorial that explains the gameplay.